"Crimson Iscariot is a man of many vices. Many horrible deeds can be credited to him. As such, the irony of his curse is that it was placed upon him after doing something very uncharacteristic. He saved somebody. More importantly, he saved the wife of the Ruler of Adela.
He saved her by killing her brother. Her brother was similar to Crimson--afflicted with some kind of curse. Thought to be leprosy, her brother was kept away from civilization, hidden in quarantine. Safe. Until he went mad. That brother went mad and broke out of his bonds and proceeded to murder the docters who tended to him.
The nurses...well, he did far worse.
He kidnapped his sister and they sailed out to sea. His disease was crippling--he was rotting at an incredible rate. His body began to change, to twist and distort into something less than human. His sister, bless her heart, never stopped trying to talk him down--even when he bit off one of her fingers. Iscariot saw the monster and saved her from a more unfortunate death--one that would be preceeded and proceeded by rape--with some healthy cannonfire.
Iscariot slew the monster, and its final act was to stab the pirate lord with it's claw. The claw melted into his skin, and forevermore Iscariot was cursed. The woman whom he'd saved cursed and refiled Iscariot. You see, the Queen of Adela and Iscariot had once been lovers, long ago, and up till that day he'd never forgotten her, even when he abandoned the Knighthood and fled to become a pirate.
He had hoped to win her back, but slaying her brother had the opposite effect. She tried to kill him, and he was forced into hiding. The disease manifested and...
Three years have since passed."